# Pulse Physiology Engine

**URL:** https://discourse.kitware.com/c/pulse-physiology-engine/5.md

[Latest](https://discourse.kitware.com/latest.md) · [Categories](https://discourse.kitware.com/categories.md)

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## [About the Pulse Physiology Engine category](https://discourse.kitware.com/t/about-the-pulse-physiology-engine-category/34)

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**Author:** [@brad.davis](https://discourse.kitware.com/u/brad.davis)\
**Replies:** 0\
**Last updated:** [October 16, 2017, 6:19pm UTC](https://discourse.kitware.com/t/about-the-pulse-physiology-engine-category/34 "2017-10-16T18:19:21Z")

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The Pulse Physiology engine is a C++ library that simulates human physiology that will drive medical education, research, and training technologies. Pulse provides physiology data for standalone applications, training s…

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## [What's New in Pulse 4.4.0 | September 30th Free Webinar](https://discourse.kitware.com/t/whats-new-in-pulse-4-4-0-september-30th-free-webinar/1685)

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**Author:** [@NickBearup](https://discourse.kitware.com/u/NickBearup)\
**Replies:** 0\
**Last updated:** [September 23, 2026, 6:56pm UTC](https://discourse.kitware.com/t/whats-new-in-pulse-4-4-0-september-30th-free-webinar/1685 "2026-09-23T18:56:47Z")

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On September 30th, from 12:00pm - 1:00pm ET, Kitware will be hosting What’s New in the Pulse Physiology Engine 4.4.0, a free webinar covering the recent updates and improvements in Pulse. Rachel Clipp, Ph.D., Jeff Webb,…

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## [Malignant Hyperthermia](https://discourse.kitware.com/t/malignant-hyperthermia/1683)

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**Author:** [@varunsesh](https://discourse.kitware.com/u/varunsesh)\
**Replies:** 0\
**Last updated:** [September 21, 2026, 11:24am UTC](https://discourse.kitware.com/t/malignant-hyperthermia/1683 "2026-09-21T11:24:28Z")

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Hi Guys, Has anyone tried to simulate Malignant Hyperthermia (MH) using Pulse Engine ? The typical case would be something like Laryngospasm (modelled as airway obstruction) is resolved and once succynlychloline is admi…

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## [Building Pulse with Visual Studio](https://discourse.kitware.com/t/building-pulse-with-visual-studio/1676)

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**Author:** [@ReiUkitaVandy](https://discourse.kitware.com/u/ReiUkitaVandy)\
**Replies:** 2\
**Last updated:** [July 20, 2026, 9:03pm UTC](https://discourse.kitware.com/t/building-pulse-with-visual-studio/1676 "2026-07-20T21:03:32Z")

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Hi Aaron. I tried rebuilding Pulse with the new ECMO simulation features using Visual Studio, but I’m running into problems that may be due to my version of Visual Studio (2026). The following error message has come up …

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## [Building as an external project dependency (C++)](https://discourse.kitware.com/t/building-as-an-external-project-dependency-c/1675)

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**Author:** [@quadrupoletensor](https://discourse.kitware.com/u/quadrupoletensor)\
**Replies:** 2\
**Last updated:** [July 10, 2026, 5:46pm UTC](https://discourse.kitware.com/t/building-as-an-external-project-dependency-c/1675 "2026-07-10T17:46:38Z")

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I’m trying to use Pulse as a dependency for a larger preexisting project, in MSVC/Visual Studio 2022. I am pulling in the Pulse engine via fetchcontent, and the files are cloned into my build directory as expected. The …

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## [Pulse for Mobile](https://discourse.kitware.com/t/pulse-for-mobile/1673)

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**Author:** [@jdyreson](https://discourse.kitware.com/u/jdyreson)\
**Replies:** 10\
**Last updated:** [June 11, 2026, 3:15pm UTC](https://discourse.kitware.com/t/pulse-for-mobile/1673 "2026-06-11T15:15:44Z")

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Hello, I see plenty of documentation around building Pulse for Android when using it in Unity or Unreal projects, but I was curious if there was anything regarding native Android/iOS? My assumption is that achieving th…

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## [Why does TissueModel::CalculateDiffusion() apply both instant and simple diffusion to O2/CO2?](https://discourse.kitware.com/t/why-does-tissuemodel-calculatediffusion-apply-both-instant-and-simple-diffusion-to-o2-co2/1671)

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**Author:** [@yifan\_sun](https://discourse.kitware.com/u/yifan_sun)\
**Replies:** 2\
**Last updated:** [May 17, 2026, 8:33am UTC](https://discourse.kitware.com/t/why-does-tissuemodel-calculatediffusion-apply-both-instant-and-simple-diffusion-to-o2-co2/1671 "2026-05-17T08:33:03Z")

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Hi Pulse Physiology Engine team, I am trying to understand the tissue gas diffusion methodology in TissueModel::CalculateDiffusion(). For gaseous substances such as O2 and CO2, the code appears to perform both instanta…

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## [Is there a way to use the simulator in Vision Pro?](https://discourse.kitware.com/t/is-there-a-way-to-use-the-simulator-in-vision-pro/1667)

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**Author:** [@FahimU80](https://discourse.kitware.com/u/FahimU80)\
**Replies:** 6\
**Last updated:** [February 6, 2026, 2:00pm UTC](https://discourse.kitware.com/t/is-there-a-way-to-use-the-simulator-in-vision-pro/1667 "2026-02-06T14:00:49Z")

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Is there a way to run my Xcode project with the engine on a simulator? It currently only runs on an actual Vision Pro which I dont always have access to.

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## [ANNSIM 2026 Modeling & Simulation in Medicine Call for Papers](https://discourse.kitware.com/t/annsim-2026-modeling-simulation-in-medicine-call-for-papers/1663)

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**Author:** [@MichelODU](https://discourse.kitware.com/u/MichelODU)\
**Replies:** 1\
**Last updated:** [January 7, 2026, 8:11pm UTC](https://discourse.kitware.com/t/annsim-2026-modeling-simulation-in-medicine-call-for-papers/1663 "2026-01-07T20:11:02Z")

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Dear members of the Pulse community, I would like to draw your attention to the Annual Modeling & Simulation (ANNSIM) Conference, which will take place on May 4-7 2026 in Orlando, Florida, as part of which, Prof. Jerz…

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## [Android 16KB Page Size Issue](https://discourse.kitware.com/t/android-16kb-page-size-issue/1662)

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**Author:** [@David\_Greco](https://discourse.kitware.com/u/David_Greco)\
**Replies:** 3\
**Last updated:** [December 18, 2025, 3:27pm UTC](https://discourse.kitware.com/t/android-16kb-page-size-issue/1662 "2025-12-18T15:27:04Z")

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Hi, we’re running into policy violations with our Android Google Play store submissions because the pulse SDK is not build with 16KB page sizes. We were able to request a short extension but are warned that in the near f…

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## [After setting Pulse\_NATIVE\_BUILD\_DIR to my macos root build directory, CMake does not configure](https://discourse.kitware.com/t/after-setting-pulse-native-build-dir-to-my-macos-root-build-directory-cmake-does-not-configure/1657)

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**Author:** [@FahimU80](https://discourse.kitware.com/u/FahimU80)\
**Replies:** 20\
**Last updated:** [December 16, 2025, 9:28pm UTC](https://discourse.kitware.com/t/after-setting-pulse-native-build-dir-to-my-macos-root-build-directory-cmake-does-not-configure/1657 "2025-12-16T21:28:48Z")

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Im trying to use the engine for a visionOS project. I built the macOS version no problem and my bin populated with protoc. As I go to make the iOS version and set my root directory to the macOSBuild and it says CMake …

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## [Failing to load PulseC (Android phone)](https://discourse.kitware.com/t/failing-to-load-pulsec-android-phone/1660)

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**Author:** [@Ayfel](https://discourse.kitware.com/u/Ayfel)\
**Replies:** 6\
**Last updated:** [December 16, 2025, 2:06pm UTC](https://discourse.kitware.com/t/failing-to-load-pulsec-android-phone/1660 "2025-12-16T14:06:09Z")

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Hi, We are facing this issue when trying to load pulse with a Unity 6 build for android phones. This is the runtime error we get (and obviously Pulse fails to work): 2025/12/15 13:59:43.837 10073 10123 Debug nativeload…

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## [Xcode iOS (from Unity) Build Errors](https://discourse.kitware.com/t/xcode-ios-from-unity-build-errors/1656)

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**Author:** [@David\_Greco](https://discourse.kitware.com/u/David_Greco)\
**Replies:** 19\
**Last updated:** [December 10, 2025, 2:39pm UTC](https://discourse.kitware.com/t/xcode-ios-from-unity-build-errors/1656 "2025-12-10T14:39:59Z")

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I’m trying to build project exported from Unity 6000.0.63f1 and when I build the Xcode project I get the following errors: (the CoreAudioTypes Framework error appears to be benign and the real issue is the missing symbol…

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## [Initializing a sick patient in PyPulse](https://discourse.kitware.com/t/initializing-a-sick-patient-in-pypulse/1655)

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**Author:** [@Student01](https://discourse.kitware.com/u/Student01)\
**Replies:** 5\
**Last updated:** [December 5, 2025, 11:37pm UTC](https://discourse.kitware.com/t/initializing-a-sick-patient-in-pypulse/1655 "2025-12-05T23:37:54Z")

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Dear forum users, We are currently working on a university project and we want to test the preset HowTo SESubstanceBolus on a sepsis patient. The problem we have each time is, that inherently, as expected, a sick patie…

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## [Issue building for Mac (Unity)](https://discourse.kitware.com/t/issue-building-for-mac-unity/1562)

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**Author:** [@Ayfel](https://discourse.kitware.com/u/Ayfel)\
**Replies:** 1\
**Last updated:** [October 22, 2025, 8:10pm UTC](https://discourse.kitware.com/t/issue-building-for-mac-unity/1562 "2025-10-22T20:10:14Z")

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Trying to build for Mac and getting the following error on build: ”Plugin ‘libPulseC.dylib’ is used from several locations: Packages/com.caffeine/3RD/PulsePhysiologyEngine/Plugins/Native/macOSi/libPulseC.dylib would be…

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## [SEMechanicalVentilation flow and pressure](https://discourse.kitware.com/t/semechanicalventilation-flow-and-pressure/1560)

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**Author:** [@di.sheng](https://discourse.kitware.com/u/di.sheng)\
**Replies:** 2\
**Last updated:** [October 21, 2025, 12:53am UTC](https://discourse.kitware.com/t/semechanicalventilation-flow-and-pressure/1560 "2025-10-21T00:53:26Z")

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Hi, For SEMechanicalVentilation, when set pressure or flow, are they airway pressure/flow or lung pressure/flow? Thank you.

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## [Install/Bin lacks essential things after successful build](https://discourse.kitware.com/t/install-bin-lacks-essential-things-after-successful-build/1559)

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**Author:** [@Shivam\_Sharma](https://discourse.kitware.com/u/Shivam_Sharma)\
**Replies:** 3\
**Last updated:** [October 15, 2025, 4:17pm UTC](https://discourse.kitware.com/t/install-bin-lacks-essential-things-after-successful-build/1559 "2025-10-15T16:17:41Z")

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I am trying to install Pulse in win11, using CMake and MSVC. After completion of process everything seems fine. Only problem is install/bin folder does not have the essential substance and other files which are generally…

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## [Pulse engine error after running mechanical ventilation over two days](https://discourse.kitware.com/t/pulse-engine-error-after-running-mechanical-ventilation-over-two-days/1557)

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**Author:** [@di.sheng](https://discourse.kitware.com/u/di.sheng)\
**Replies:** 2\
**Last updated:** [September 9, 2025, 2:25pm UTC](https://discourse.kitware.com/t/pulse-engine-error-after-running-mechanical-ventilation-over-two-days/1557 "2025-09-09T14:25:47Z")

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Hi, I use the pulse engine to run the mechanical ventilation with patient age/weight/height and feed with real time flow/pressure data, however after two nights of running the engine, there are engine erorrs": \[ERROR\] …

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## [Creating an initial state for use in Unity](https://discourse.kitware.com/t/creating-an-initial-state-for-use-in-unity/1550)

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**Author:** [@CharlieWSH](https://discourse.kitware.com/u/CharlieWSH)\
**Replies:** 7\
**Last updated:** [August 29, 2025, 2:59pm UTC](https://discourse.kitware.com/t/creating-an-initial-state-for-use-in-unity/1550 "2025-08-29T14:59:12Z")

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Hi, I am using the Pulse engine in unity and am trying to create an initial state for my patient with specific Heart rate and blood pressure for a simulation. I have been trying to amend one of the existing JSON files(in…

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## [HumMod vs BioGears vs Pulse](https://discourse.kitware.com/t/hummod-vs-biogears-vs-pulse/1547)

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**Author:** [@Malhar\_K](https://discourse.kitware.com/u/Malhar_K)\
**Replies:** 3\
**Last updated:** [August 26, 2025, 3:30pm UTC](https://discourse.kitware.com/t/hummod-vs-biogears-vs-pulse/1547 "2025-08-26T15:30:04Z")

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I am a computer science major trying to understand what pros and cons each simulator provides as I have to work with them for custom use required by a lab. Any insights would be appreciated!

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## [SEAdvanceTime as a regular SEAction?](https://discourse.kitware.com/t/seadvancetime-as-a-regular-seaction/1553)

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**Author:** [@Ayfel](https://discourse.kitware.com/u/Ayfel)\
**Replies:** 4\
**Last updated:** [August 25, 2025, 1:46pm UTC](https://discourse.kitware.com/t/seadvancetime-as-a-regular-seaction/1553 "2025-08-25T13:46:04Z")

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Is there a way to use this to advance time without using engine.AdvanceTime\_s? (This is for the Unity implementation) we have a whole framework about actions that abstracts using SEAction, and I figured this could be us…

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## [Scenario State generation](https://discourse.kitware.com/t/scenario-state-generation/1536)

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**Author:** [@Ayfel](https://discourse.kitware.com/u/Ayfel)\
**Replies:** 10\
**Last updated:** [August 7, 2025, 11:48pm UTC](https://discourse.kitware.com/t/scenario-state-generation/1536 "2025-08-07T23:48:00Z")

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So I used to be able to do the following in Unity to create my state but it seems like a lot of these methods are now gone? Any guidance on how to achieve the same? public void GenerateEditorStateFromScenario() …

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## [Pulse Engine on WebGL (Unity build)](https://discourse.kitware.com/t/pulse-engine-on-webgl-unity-build/1135)

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**Author:** [@smoses](https://discourse.kitware.com/u/smoses)\
**Replies:** 23\
**Last updated:** [August 12, 2025, 9:46pm UTC](https://discourse.kitware.com/t/pulse-engine-on-webgl-unity-build/1135 "2025-08-12T21:46:57Z")

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Has anyone had success running Pulse Engine in a WebGL build (Unity), or otherwise running in a web application?

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## [Pulling data with time step of 1 hour](https://discourse.kitware.com/t/pulling-data-with-time-step-of-1-hour/1529)

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**Author:** [@Shivam\_Sharma](https://discourse.kitware.com/u/Shivam_Sharma)\
**Replies:** 6\
**Last updated:** [July 23, 2025, 5:02pm UTC](https://discourse.kitware.com/t/pulling-data-with-time-step-of-1-hour/1529 "2025-07-23T17:02:28Z")

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Hi, I am using Pulse Python bindings for simulations. I am trying to simulate patients who have VAP in their lungs. However, I need data in time steps of 1 hour. Is there any way possible to get that data faster? Because…

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## [Free Webinar for Pulse Physiology Engine - June 4](https://discourse.kitware.com/t/free-webinar-for-pulse-physiology-engine-june-4/1505)

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**Author:** [@rachel.clipp](https://discourse.kitware.com/u/rachel.clipp)\
**Replies:** 0\
**Last updated:** [May 20, 2025, 3:24pm UTC](https://discourse.kitware.com/t/free-webinar-for-pulse-physiology-engine-june-4/1505 "2025-05-20T15:24:23Z")

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Join us on June 4 at noon for a free live Webinar about the Pulse Physiology Engine. Register Now With the Pulse Physiology Engine, you can customize patient models, dynamically apply physiological changes, and outp…

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## [Not able to use python bindings](https://discourse.kitware.com/t/not-able-to-use-python-bindings/1495)

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**Author:** [@Shivam\_Sharma](https://discourse.kitware.com/u/Shivam_Sharma)\
**Replies:** 3\
**Last updated:** [May 16, 2025, 6:34pm UTC](https://discourse.kitware.com/t/not-able-to-use-python-bindings/1495 "2025-05-16T18:34:00Z")

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I tried following the steps listed on your site for python bindings install but still not able to access it. I am having windows 11, latest Cmake, Python 3.10, and VS2022. Here is the error log when i am trying to run …

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## [What is the format/syntax for the "modifier\_file" in the modification classes?](https://discourse.kitware.com/t/what-is-the-format-syntax-for-the-modifier-file-in-the-modification-classes/1480)

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**Author:** [@ezcawi](https://discourse.kitware.com/u/ezcawi)\
**Replies:** 8\
**Last updated:** [April 8, 2025, 3:04pm UTC](https://discourse.kitware.com/t/what-is-the-format-syntax-for-the-modifier-file-in-the-modification-classes/1480 "2025-04-08T15:04:22Z")

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Hello! I am looking to modify the Cerebral Perfusion Pressure in my pulse simulation by adding/subtracting values. There’s a class, “SECardiovascularMechanicsModification”, used to modify the cardiovascular system here: …

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## [Simulate blood pooling in legs](https://discourse.kitware.com/t/simulate-blood-pooling-in-legs/1482)

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**Author:** [@j.dunn](https://discourse.kitware.com/u/j.dunn)\
**Replies:** 2\
**Last updated:** [April 3, 2025, 3:23pm UTC](https://discourse.kitware.com/t/simulate-blood-pooling-in-legs/1482 "2025-04-03T15:23:04Z")

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I’m interested in trying to simulate blood pooling in the lower legs. My thoughts were to change right/left leg vasculature volume or pressure, and decrease the outflow, but I don’t see a clear way to do this. Is it pos…

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## [PulseC.dylib cannot be used](https://discourse.kitware.com/t/pulsec-dylib-cannot-be-used/1464)

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**Author:** [@andy](https://discourse.kitware.com/u/andy)\
**Replies:** 8\
**Last updated:** [February 28, 2025, 5:53am UTC](https://discourse.kitware.com/t/pulsec-dylib-cannot-be-used/1464 "2025-02-28T05:53:51Z")

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We made some changes to the source code and then compiled the library（PulseC.dylib）. It runs well on other platforms, but there is an issue on the Mac platform. The error is shown in the image below. We have been looking…

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## [Windows 11 install?](https://discourse.kitware.com/t/windows-11-install/1441)

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**Author:** [@Raw-Steel](https://discourse.kitware.com/u/Raw-Steel)\
**Replies:** 3\
**Last updated:** [January 24, 2025, 3:13pm UTC](https://discourse.kitware.com/t/windows-11-install/1441 "2025-01-24T15:13:07Z")

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Hi, I am a clinician and not a coder but would like to install the Pulse Physiology Engine in an attempt to make a Cardiopulmonary Bypass Simulator. Can you please list all the necessary programs I need to install befo…

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