# covid related examples
**URL:** https://discourse.kitware.com/t/covid-related-examples/446
**Category:** Pulse Physiology Engine
**Created:** [April 28, 2020, 8:28pm UTC](https://discourse.kitware.com/t/covid-related-examples/446 "2020-04-28T20:28:55Z")
**Posts on this page:** 6
**Page:** 1
### Author:  [@bob.marinier](https://discourse.kitware.com/u/bob.marinier)
#### Post date: [April 28, 2020, 8:28pm UTC](https://discourse.kitware.com/t/covid-related-examples/446/1 "2020-04-28T20:28:55Z")
Are there any covid-related examples/scenarios for pulse? If not covid itself, then other similar diseases/viruses (e.g., flu, the original SARS, etc.)? In the absence of existing example, any advice on how such a thing could be modeled in pulse?
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### Author:  [@coolwebb](https://discourse.kitware.com/u/coolwebb)
#### Post date: [April 29, 2020, 2:30pm UTC](https://discourse.kitware.com/t/covid-related-examples/446/2 "2020-04-29T14:30:58Z")
Yes. We just completed a COVID-19 multipatient ventilation (i.e., two patients sharing one ventilator) study. We plan to release a manuscript detailing the results very soon. The code has been merged into the 3.x branch. See the [ReadMe](https://gitlab.kitware.com/physiology/engine/-/blob/3.x/src/cpp/study/multiplex_ventilation/ReadMe.md) for details.
To model COVID-19 pathophysiology, we added the ability to set/override the respiratory system resistance and compliance and exposed the alveolar gas exchange and pulmonary shunt fraction modifiers for direct manipulation. This allows PaO2/FiO2 ratios consistent with the ARDS Berlin criteria, but with the atypical dissociation with well-preserved lung mechanics (i.e., compliance) seen in COVID-19 patients.
We also created a Jupyter Notebook and posted it in [Binder](https://mybinder.org/v2/git/https%3A%2F%2Fgitlab.kitware.com%2Fphysiology%2Fjupyter.git/master) (select Multiplex\_Ventilation.ipynb and hit Run). We plan to continue updating this.
I’m adding a COVID-19 HowTo in the SDK this week and will let you know when it’s up.
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### Author:  [@bob.marinier](https://discourse.kitware.com/u/bob.marinier)
#### Post date: [April 30, 2020, 1:11pm UTC](https://discourse.kitware.com/t/covid-related-examples/446/3 "2020-04-30T13:11:50Z")
This is great! Is there a specific timeline for the official 3.x release?
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### Author:  [@abray](https://discourse.kitware.com/u/abray)
#### Post date: [April 30, 2020, 1:38pm UTC](https://discourse.kitware.com/t/covid-related-examples/446/4 "2020-04-30T13:38:04Z")
I am in the process of landing some branches
End of May at the latest.
Note, 3.x has all the models necessary already.
I also added the support in Java for setting the data directory
I still want to address some of your other issues you created
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### Author:  [@coolwebb](https://discourse.kitware.com/u/coolwebb)
#### Post date: [April 30, 2020, 7:29pm UTC](https://discourse.kitware.com/t/covid-related-examples/446/5 "2020-04-30T19:29:49Z")
The new COVID-19 HowTo is up: [https://gitlab.kitware.com/physiology/engine/-/blob/3.x/src/cpp/howto/HowTo-COVID19Ventilated.cpp](https://gitlab.kitware.com/physiology/engine/-/blob/3.x/src/cpp/howto/HowTo-COVID19Ventilated.cpp)
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### Author:  [@coolwebb](https://discourse.kitware.com/u/coolwebb)
#### Post date: [May 26, 2020, 5:32pm UTC](https://discourse.kitware.com/t/covid-related-examples/446/6 "2020-05-26T17:32:21Z")
Our preprint titled _Computational Simulation to Assess Patient Safety of Uncompensated COVID-19 Two-patient Ventilator Sharing Using the Pulse Physiology Engine_ has posted on medRxiv: [https://medrxiv.org/cgi/content/short/2020.05.19.20107201v1](https://medrxiv.org/cgi/content/short/2020.05.19.20107201v1)