# Oversedation Substance doubts.

**URL:** https://discourse.kitware.com/t/oversedation-substance-doubts/1365
**Category:** Pulse Physiology Engine
**Created:** [September 18, 2024, 12:23pm UTC](https://discourse.kitware.com/t/oversedation-substance-doubts/1365 "2024-09-18T12:23:58Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![NucleusDev](https://discourse.kitware.com/letter_avatar_proxy/v4/letter/n/ba8739/32.png) [@NucleusDev](https://discourse.kitware.com/u/NucleusDev)
#### Post date: [September 18, 2024, 12:23pm UTC](https://discourse.kitware.com/t/oversedation-substance-doubts/1365/1 "2024-09-18T12:23:58Z")

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No matter What i set the values for Dosage, Concentration Oversedation seems to be producing the same result is this intentional ?

Additionally, The Second does seems to have no effect on the patient

 ![image](https://discourse.kitware.com/uploads/default/original/1X/6a8ea778ea936146b12f8922ec18a661bc38b11a.png)

This is the result when my params are the default or with absurd numbers  
The Absurd Setup

```auto
const SESubstance* oversed = pe->GetSubstanceManager().GetSubstance("Oversedation");

//// Create a substance bolus action to administer the substance
SESubstanceBolus bolus(*oversed);
bolus.GetConcentration().SetValue(10000,MassPerVolumeUnit::ug_Per_mL);
bolus.GetDose().SetValue(1000,VolumeUnit::mL);
bolus.SetAdminRoute(eSubstanceAdministration_Route::Intravenous);
bolus.GetAdminDuration().SetValue(50.0, TimeUnit::s);

```

The Non Absurd Setup

```auto
 const SESubstance* oversed = pe->GetSubstanceManager().GetSubstance("Succinylcholine");

 // Create a substance bolus action to administer the substance
 SESubstanceBolus bolus(*oversed);
 bolus.GetConcentration().SetValue(4820,MassPerVolumeUnit::ug_Per_mL);
 bolus.GetDose().SetValue(20,VolumeUnit::mL);
 bolus.SetAdminRoute(eSubstanceAdministration_Route::Intravenous);
```

---

<div class="post-metadata">

### Author: ![abray](https://discourse.kitware.com/user_avatar/discourse.kitware.com/abray/32/12_2.png) [@abray](https://discourse.kitware.com/u/abray)
#### Post date: [September 18, 2024, 1:32pm UTC](https://discourse.kitware.com/t/oversedation-substance-doubts/1365/2 "2024-09-18T13:32:57Z")

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Pulse does not model the overdosing of drugs, it maxes out effects at the maximum recommended dose. So going above that value will result in the same PD effects. [You can read more here.](https://pulse.kitware.com/_drugs_methodology.html#autotoc_md543)

The `Oversedation` substance was created to simulate the physiology of a generic oversedation within our current drug modelling methodology.

So you will not get any more effect by rasing dosages past the Cmax  
Although you can get a range of effects between that max dosage and 0